The Relationship Between Duration of Hypertension and Serum Creatinine, Urea, and Estimated Glomerular Filtration Rate (EGFR) in Hypertensive Patients
DOI:
https://doi.org/10.59141/jiss.v7i6.2394Keywords:
Hypertension, Creatinine, Urea, EGFRAbstract
Hypertension, defined as systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg, affects 34.1% of Indonesia's population according to the Indonesian Basic Health Research. Uncontrolled and long-standing high blood pressure can damage the glomerular structure, leading to decreased kidney function characterized by increased urea and creatinine levels, as well as a reduced glomerular filtration rate (eGFR), which is the main indicator for staging chronic kidney disease. The purpose of the study is to analyze the relationship between the duration of hypertension and kidney function biomarkers, namely creatinine, urea, and estimated glomerular filtration rate (eGFR), in hypertensive patients. This research method uses an observational analytical design with a purposive sampling technique, involving a total of 30 patients with grade 1 and grade 2 hypertension. The results of the examination of kidney function biomarkers (creatinine, urea, and eGFR) in relation to the duration of hypertension, based on the nonparametric Kendall's tau correlation test, showed no significant relationship between creatinine values and duration of hypertension (p = 0.061, p > 0.05), nor between urea values and duration of hypertension (p = 0.198, p > 0.05); however, a significant relationship was found between eGFR and duration of hypertension (p = 0.006, p < 0.05). Thus, it can be concluded that eGFR is a potential biomarker in laboratory examinations for assessing the risk of kidney damage complications in hypertensive patients. It is recommended that people with hypertension undergo regular kidney function checks in order to reduce the risk of long-term complications.
References
Ameer, O. Z. (2022). Hypertension in chronic kidney disease: What lies behind the scene. Frontiers in Pharmacology, 13(October), 1–28. https://doi.org/10.3389/fphar.2022.949260
Aris, R., Yanti, A. K. E., & Adnan, E. (2024). Pengaruh Pemberian Jus Kurma Terhadap Pasien Dengan Tekanan Darah Tinggi Di Puskesmas Pengarayaan. Jurnal Kesehatan Tambusai, 5(1), 2342–2350.
Aronow, W. S. (2017). Association of obesity with hypertension. Annals of Translational Medicine, 5(17), 11–13. https://doi.org/10.21037/atm.2017.06.69
Barends, I. D., Purwanto, D. S., Assa, Y. A., & Ratulangi, U. S. (2026). Hubungan Kadar Kreatinin Darah dengan Tekanan Darah pada Pasien Penyakit Ginjal Kronik Dengan Hipertensi di RSUD ODSK Provinsi Sulawesi Utara Menurut Kidney Disease Outcome Quality Initiative ( KDOQI ) dan Kidney Disease Improving Global Outcomes ( KDIGO . 5(November 2025), 423–432.
Franzen, S., Naslund, E., Wang, H., & Frithiof, R. (2021). Prevention of hemorrhage-induced renal vasoconstriction and hypoxia by angiotensin II type 1 receptor antagonism in pigs. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 321(1), R12–R20. https://doi.org/10.1152/ajpregu.00073.2021
Gupta, A., Sontakke, T., Acharya, S., & Kumar, S. (2024). A comprehensive review of biomarkers for chronic kidney disease in older individuals: Current perspectives and future directions. Cureus, 16(9).
Hocher, B., & Adamski, J. (2017). Metabolomics for clinical use and research in chronic kidney disease. Nature Reviews Nephrology, 13(5), 269–284.
Kemenkes RI. (2021). Keputusan Menteri Kesehatan Republik Indonesia Nomor HK.01.07 Tahun 2021 Tentang Pedoman Nasional Pelayanan Kedokteran Tata Laksana Hipertensi Dewasa. Kementerian Kesehatan Republik Indonesia, 1–85.
Kemenkes RI. (2023). Pedoman Nasional Pelayanan Kedokteran Tata Laksana Penyakit Ginjal Kronik. Keputusan Menteri Kesehatan Republik Indonesia, 11, 1–189.
Ladesvita, F., Anggraeni, D. T., & Lima, F. (2020). Jurnal Kesehatan Medika Saintika Jurnal Kesehatan Medika Saintika. Jurnal Kesehatan Medika Saintika, 11(2), 253–257.
Maiseri, A., Mgonda, Y., & Charles, W. (2024). Pattern of Kidney Disease Among Hypertensive Patient Attending Cardiac Clinics in Dar-Es Salaam. International Internal Medicine Journal, 2(8), 01–07. https://doi.org/10.33140/iimj.02.08.02
Manongga, E. R. R., Nelwan, J. E., & Kaunang, W. P. J. (2024). Gambaran Determinan Hipertensi di Puskesmas Amurang Kabupaten Minahasa Selatan. 5, 29–36.
Pandya, D., Nagrajappa, A. K., & Ravi, K. S. (2016). Assessment and correlation of urea and creatinine levels in saliva and serum of patients with chronic kidney disease, diabetes and hypertension–a research study. Journal of Clinical and Diagnostic Research: JCDR, 10(10), ZC58.
Restia, P, Y., & Cut Warnaini. (2023). Jurnal Biologi Tropis. Jurnal Biologi Tropis, 21(3), 1073–1080.
Rivaldi, R., Cahyadi, E., & Saida, S. A. (2025). Hubungan Antara Hipertensi dan Penyakit Ginjal Kronis Pada Pasien di Rumah Sakit Meuraxa Kota Banda Aceh. Future Academia : The Journal of Multidisciplinary Research on Scientific and Advanced, 3(4), 1949–1954. https://doi.org/10.61579/future.v3i4.629
Salsabila, A. Z., Sulistyaningsih, D. R., & Wahyuningsih, I. sri. (2025). Essentia : Journal of Medical Practice and Research Hubungan Tekanan Darah dan Lama Menderita dengan Laju Filtrasi Glomerulus Pasien Hipertensi. 1(2).
Sekula, P., Goek, O.-N., Quaye, L., Barrios, C., Levey, A. S., Römisch-Margl, W., Menni, C., Yet, I., Gieger, C., & Inker, L. A. (2015). A metabolome-wide association study of kidney function and disease in the general population. Journal of the American Society of Nephrology: JASN, 27(4), 1175.
Silviana, T., & Kodim, N. (2019). Prevalensi dan Karakteristik Hipertensi Pada Usia Dewasa Muda di Indonesia. Tarumanagara Medical Journal, 1(2), 396.
Sinta, N., Syahril, E., & Irmayanti, I. (2022). Hubungan Derajat Hipertensi Dengan Kadar Ureum Dan Kreatinin. Indonesian Journal of Health, 2(03), 135–146. https://doi.org/10.33368/inajoh.v2i03.70
Unger, T., Borghi, C., Charchar, F., Khan, N. A., Poulter, N. R., Prabhakaran, D., Ramirez, A., Schlaich, M., Stergiou, G. S., Tomaszewski, M., Wainford, R. D., Williams, B., & Schutte, A. E. (2020). 2020 International Society of Hypertension Global Hypertension Practice Guidelines. Hypertension, 75(6), 1334–1357. https://doi.org/10.1161/HYPERTENSIONAHA.120.15026
WHO. (2025). WHO global report on hypertension 2025. In The Lancet (Vol. 406, Issue 10517). https://doi.org/10.1016/S0140-6736(25)02208-1
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